National Cancer Tissue Biobank (NCTB), a state-of-the-art non-profit community based tissue bank, is a joint initiative of Department of Science and Technology (DST), Government of India and Indian Institute of Technology Madras (IITM). The biobank collects cancer tissue samples with consent from patients diagnosed with cancer. Information about the previous medical history and treatment of the donors is also documented along with the tissue samples. Tissue samples collected following surgery is in excess of what is required for diagnosis and would otherwise be discarded.
NCTB is first of its kind facility in India and aiming to provide researchers with high quality of cancer tissues and the patient data in order to facilitate cancer research that will lead to improvements in cancer diagnosis and treatment. A panel of scientists and doctors (Steering committee of the biobank) must approve that the project is scientifically worthwhile and ethics committee must approve the project before bio-specimens are provided to researchers. NCTB is located in the Department of Biotechnology, IITM which has a vibrant academic and technology ecosystem.
Dr. S. Mahalingam
Professor-In-Charge (National Cancer Tissue Biobank)
- May 2010 to Present : Professor, Dept. of Biotechnology, Indian Institute of Technology Madras, Chennai.
- May 2007 - May 2010 : Associate Professor, Dept. of Biotechnology, Indian Institute of Technology Madras, Chennai.
- May 2005 - May 2007 : Staff Scientist-V, Centre DNA Fingerprinting and Diagnostics, Hyderabad.
- Aug - Dec. 2003 : Visiting Scientist, Institute of Molecular and Cellular Biology, Singapore.
- Mar - May 2002 : Visiting Scientist, University of Pittsburgh, Pittsburgh, USA.
- Oct 2000 - Apr 2005 : Staff Scientist-IV, Centre DNA Fingerprinting and Diagnostics, Hyderabad.
- 1997 - 2000 : Research Associate, University of Alabama, Birmingham, USA.
- 1996 - 1997 : Research Associate, University of Pennsylvania, Philadelphia, USA.
- 1993 - 1995 : Postdoctoral Fellow, Thomas Jefferson Univ, Philadelphia, USA.
- 1988 - 1992 : Graduate student, Madurai Kamaraj Univ. India.
- Outstanding Research Investigator award (2009), Department of Atomic Energy, Government of India.
- Member, National advisory committee, DST, Government of India (2010 - 2013).
- Export member, Medical Biotechnology task force, DBT, Government of India (2009 - 2012).
- Chairman, Board of Studies in Biotechnology, University of Madras, Chennai (2009 - 2012).
- Elected member, Guha research Conference, India (2007 - 2010).
- Elected member, Immunology forum of India (2007 - 2010).
- Cellular Receptor for HIV-1 Vpr essential for G2/M phase transition of the cell cycle. (# 08/949,202) (D.B. Weiner, S. Mahalingam, V. Ayyavoo and M. Patel)US patent.
- Functional fragments of HIV-1 Vpr protein and the method of using the same. (S. Mahalingam, V. Ayyavoo, M. Patel, T. Kieber-Emmons and D.B.Weiner) US Patent.
- Novel nucleolar GTPase and methods for controlling proliferation of cells. (Balasundaram. D. Du.X., and Mahalingam. S.) US patent filed.
Other scientific activities
- Editorial member, International Journal of Virology- Academic Journals, New York (2005-2009).
- Ad-hoc reviewer for (a) for Virology, Academic Press (b) Journal of Virology, American Society for Microbiology.
- Organized the 5th Transcriptional Assembly meeting, August 2002, CDFD, Hyderabad (as an organizer).
- Organized the “International conference on HIV pathogenesis” December 2006, Hyderabad (as an organizer).
- Organized the 77th Society of Biological Chemists of India meeting at IIT-Madras Chennai, Dec 2008 (as an co-organizer).
- Organized the “International conference on Cancer Biology: Molecular Mechanisms and Novel Therapeutics” February 2010 at IIT-Madras, Chennai (as an organizer).
- Organized the “International conference on Cancer Biology: Molecular Mechanisms and Novel Therapeutics” February 2014 at IIT-Madras, Chennai (as an organizer).
(Team to be updated)
Patient medical information will be confidential and are stored securely. Samples are coded and anonymised. The biobank database links the sample code to a patient’s medical information and the identity will not made available to researchers. Databases will comply with the Data Protection Act.
“A Cancer Free Future”
NCTB aims to centralize and standardize collection of samples by maintaining large quantity of high quality biological samples for research and discovery.
- Integrity- A reliable and ethical approach to biobanking
- Quality- Provide quality tissue samples to researchers
- Diversity- Availability of diverse range of tissue samples
The mission of NCTB is to advance the field of biobanking in support of research improving cancer care and management.
The goals of NCTB are:
- To prospectively collect and store tissue samples from donors of all types of cancer and make these materials available to investigators for basic and clinical cancer research.
- Encourage high professional standards and be renown in biobanking.
- Identify problems in the biobanking field and provide solutions.
NCTB collaborates with many leading medical institutions for research and development in early bio-marker identification, drug target identification and assessment of cancer.
Collaborating Medical Centers:
- Chennai Breast Clinic, MRC Nagar, Chennai
- Southern Railway HQ Hospital, Chennai
- Rajiv Gandhi Govt. General Hospital (Madras Medical College), Chennai
- Kumaran Hospital, Chennai
- Anderson Diagnostics, Chennai
- Kanchi Kamakoti Child Trust Hospital, Chennai
- Global Hospital, Chennai
- Dr. Kamakshi Memorial Hospital, Chennai